Zoladex, Provenge, Xgeva, Zometa Prostate Cancer Market Analysis Forecast to 2022

PharmaPoint Drug Evaluation report, “Zoladex, Provenge, Xgeva, Zometa (Prostate Cancer) – Forecast and Market Analysis to 2022″. The recent approvals of second-line metastatic castration-resistant prostate cancer (mCRPC) therapies like J&J’s Zytiga (abiraterone acetate) and Medivation/Astellas’ Xtandi (enzalutamide) will drive strong market growth over the next decade. These safe and orally administered treatments will provide safety and convenience benefits over the current standard of care, chemotherapy with docetaxel, while prolonging the overall survival of patients with mCRPC. The December 12, 2012 FDA approval of Zytiga for the added indication of chemotherapy-naïve mCRPC marks the onset of a new treatment paradigm for the disease, in which chemotherapy is relegated to second-line therapy and beyond. For patients with earlier-stage prostate cancer, androgen deprivation therapy with LHRH agonists and first-generation antiandrogens remains the standard of care for suppressing testosterone levels and temporarily controlling the disease.

Zometa Prostate Cancer Market Analysis

Novartis’ Zometa is a bisphosphonate indicated for the treatment of bone metastases in patients with CRPC, other solid tumors, and multiple myeloma. Its active ingredient, zoledronic acid, inhibits osteoclastic activity and induces apoptosis in osteoclasts, the cells responsible for bone resorption (Zometa Prescribing Information, 2012). This helps prevent the SREs that are a common symptom of bone metastases. Zometa has also been shown to inhibit the increase in osteoclast activity resulting from various stimulatory factors released by tumors. Although Zometa has been a blockbuster, worldwide patent expiries between 2012 and 2013 will open the door for generic competition and undoubtedly erode its sales (Novartis Annual Report, 2011).

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Xgeva Prostate Cancer Market Analysis

Prostate cancer frequently metastasizes to the bones, increasing the likelihood of skeletal fractures. Amgen’s Xgeva is a human Monoclonal Antibody (mAb) that binds to RANKL, a protein produced by osteoclasts involved in bone resorption, and prevents it from activating its receptor, RANK, on the osteoclast surface. This prevents the osteoclasts from breaking down bone and causing SREs (Xgeva Prescribing Information, 2010).

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Provenge Prostate Cancer Market Analysis

Dendreon’s Provenge is the first FDA-approved therapeutic cancer vaccine, and is a treatment for mCRPC. It consists of the patient’s own immune cells, which have been activated against Prostatic Acid Phosphatase (PAP), a protein found in prostate cancer cells (Provenge Prescribing Information, 2011). These activated immune cells are then infused back into the patient and induce an immune response against the prostate cancer cells.

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Zoladex Prostate Cancer Market Analysis

AstraZeneca’s Zoladex is a subcutaneous implant that delivers goserelin acetate, a synthetic analog of LHRH. It is classified as an LHRH receptor agonist (Zoladex Prescribing Information, 2010). It binds to the LHRH receptor and prevents the pituitary gland from secreting luteinizing hormone. Without luteinizing hormone, the testes do not produce testosterone. Since testosterone is known to drive the progression of prostate cancer, LHRH analogs are commonly used in ADT regimens. Zoladex is commonly used to control hormone-sensitive prostate cancer, and to maintain castrate levels of testosterone in patients with CRPC.

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Scope

- Overview of Prostate cancer, including epidemiology, etiology, symptoms, diagnosis, pathology and treatment guidelines as well as an overview on the competitive landscape.
- Detailed information on Xgeva including product description, safety and efficacy profiles as well as a SWOT analysis.
- Sales forecast for Xgeva for the top nine countries from 2012 to 2022.
- Sales information covered for the US, Japan, UK, France, Germany, Spain, Italy , Canada, and Australia

Reasons to buy

- Understand and capitalize by identifying products that are most likely to ensure a robust return
- Stay ahead of the competition by understanding the changing competitive landscape for Prostate cancer
- Effectively plan your M&A and partnership strategies by identifying drugs with the most promising sales potential
- Make more informed business decisions from insightful and in-depth analysis of Xgeva performance
- Obtain sales forecast for Xgeva from 2012-2022 in nine markets (US, Japan, UK, France, Germany, Spain, Italy , Canada, and Australia)